Mowla A, Shakibajahromi B, Arora A, et al. - Since the safety of intravenous thrombolysis (IVT) within 3–4.5 hours of stroke onset in patients ≥ 80 years is still debatable, researchers conducted this retrospective study to explore the correlation of symptom onset-to-treatment time with the symptomatic intracranial hemorrhage (sICH), poor outcome, and mortality in patients ≥ 80 years. Patients treated with IVT following stroke have been registered. Two hundred sixty-five of the 834 patients were over the age of 80. IVT within 3–4.5 hours in patients ≥ 80 years is not linked to increased sICH, poor outcome, and mortality compared with the early time window, and also compared to the younger patients in 3–4.5 hours window period. In this age group, the decision to administer IVT should not be made solely on the basis of stroke onset timing.