Itagaki K, Sekiryu T, Kasai A, et al. - Researchers conducted this prospective study to assess the three-year outcome after intravitreal aflibercept injection (IAI) for neovascular age-related macular degeneration (nAMD). Forty-nine treatment-naïve nAMD patients (50 eyes) have been registered. For 36 months, 29 eyes of 28 patients have been successfully followed up. The nAMD subtypes involved 15 eyes with typical AMD and 14 eyes with polypoidal choroidal vasculopathy. Findings suggested that long-term aflibercept injection may achieve visual improvement and decrease the thickness of the retina and choroid in nAMD. Morphological improvement of these tissues may not be enough over the long term to sustain earlier visual improvement.