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Three-dimensional visualisation of the fetal heart using prenatal MRI with motion-corrected slice-volume registration: A prospective, single-centre cohort study

The Lancet Apr 25, 2019

Lloyd DFA, et al. - As an adjunct to fetal echocardiography in the diagnosis of congenital heart disease, researchers studied the combination of prenatal MRI with a novel, motion-corrected three-dimensional (3D) image registration software. This is the largest study investigating the use of prenatal MRI in congenital heart disease fetuses. A tertiary fetal cardiology unit has been used to recruit pregnant women carrying a fetus with known or suspected congenital heart disease. One hundred one patients were referred for MRI between October 8, 2015, and June 30, 2017, of which 85 were eligible and had fetal MRI. According to results, standard fetal MRI with open-source image processing software is a reliable method of generating fetal vasculature high-resolution 3D imaging. Compared to source two-dimensional MRI data, the 3D volumes display good ultrasound spatial agreement and significantly improved visualization and diagnostic quality. Findings suggested that this freely available combination needs minimal infrastructure, and gives safe, powerful, and highly complementary imaging of the fetal cardiovascular system.
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