Stahl M, et al. – The present study’s objective was to examine the feasibility of lung clearance index (LCI) in infants and preschoolers with and without cystic fibrosis (CF) in a three–center setting. This investigation supported the feasibility of LCI as a multicenter endpoint in clinical trials in infants and preschoolers with CF.

Methods

• Following central training, standardized SF₆-MBW measurements were performed in seventy-three sedated children (ten controls, forty-nine with CF and fourteen with other lung diseases), mean age 2.3 ± 1.2 years across 3 centers, and information were inspected centrally.

Results

• According to the findings obtained, overall success rate of LCI measurements was 91.8% ranging from 78.9% to 100% across study sites.
• It was observed in the findings that LCI was increased in patients with CF (P < 0.05) and with other lung diseases (P < 0.05) compared to controls.