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Third trimester fetal cardiac blood flow and cardiac outcomes in school-age children assessed by magnetic resonance imaging

Journal of the American Heart Association Aug 21, 2019

Toemen L, Jelic G, Kooijman MN, et al. - In this population-based prospective cohort study, researchers focused on the links of third trimester placental and fetal cardiac hemodynamics with cardiac outcomes in school-age children. This study included 547 mothers and their children. Findings revealed the association of higher third-trimester umbilical artery resistance with higher childhood right ventricular ejection fraction, but not with other cardiac outcomes. Lower childhood left ventricular ejection fraction and higher left ventricular mass-to-volume ratio were reported in correlation with higher third-trimester fetal left cardiac output. Higher childhood right ventricular ejection fraction was observed in relation to a higher third-trimester fetal tricuspid valve E/A ratio. Possible long-term influences of fetal cardiac fetal blood flow redistribution on cardiac structure and function were suggested in this study. These findings are recommended to be considered as hypothesis-generating.
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