Purtskhvanidze K, et al. – This study dealt with the assessment of retinal layer thickness with optical coherence tomography (OCT), in eyes with macula–off retinal detachment after silicone oil (SiO) or gas endotamponade. The findings revealed that inner retinal layers in the fovea/parafovea were markedly thinner in the SiO group. The elucidation of possible retinal adverse effects of SiO tamponade required advanced research.