Won GH, et al. - The diagnostic utility of theta-phase gamma-amplitude coupling (TGC) as a neurophysiological marker was evaluated in neuroleptic-naïve schizophrenia patients. Among these patients, the resting-state TGC value was increased compared to that in healthy controls and had a higher discriminating ability than the other parameters. These findings could be associated with the compensatory hyper-arousal patterns of the dysfunctional default-mode network (DMN) in schizophrenia. Thus, resting-state TGC was a promising neurophysiological marker of schizophrenia.