Scarpa A, Cassandro C, De Luca P, et al. - In the present study, the researchers sought to assess the effectiveness on symptom control of intravenous glycerol in a sample of individuals with definite unilateral Meniere disease (MD) not responsive to dietary restrictions. Participants in the study were 40 patients with unilateral intractable MD. Following audio-vestibular examination, patients were treated with intravenous 10% glycerol with 0.9% sodium chloride, 0.5 g/kg ml once daily for 2 consecutive days every 15 days for six months. According to the 2015 Equilibrium Committee criteria, vertigo attacks were assessed before and after therapy and categorized into classes A–F. Tinnitus and quality of life were assessed through the Tinnitus Handicap Inventory and the Functionality Level Scale questionnaires. No hearing impairment was observed in all patients treated. After treatment, quality of life improved according to the administered questionnaires. In the study, two consecutive days of intravenous infusion of glycerol every fifteen days for six months based on the patient's weight improved vertigo attacks and decreased the discomfort caused by tinnitus increasing quality of life in patients with unilateral MD unresponsive to dietary constraints.