Scarpa A, Cassandro C, De Luca P, et al. - In the present study, the researchers sought to assess the effectiveness on symptom control of intravenous glycerol in a sample of individuals with definite unilateral Meniere's disease (MD) not responsive to dietary restrictions. Participants in the study were 40 patients with unilateral intractable MD. Following audio-vestibular examination, patients were treated with intravenous 10% glycerol with 0.9% sodium chloride, 0.5 g/kg ml once daily for 2 consecutive days every fifteen days for six months. Through the Tinnitus Handicap Inventory and the Functionality Level Scale questionnaires, tinnitus and quality of life were assessed. In the study, two consecutive days of intravenous infusion of glycerol every fifteen days for six months, based on the patient's weight, improved vertigo attacks and reduced the discomfort caused by tinnitus increasing quality of life in patients with unilateral MD unresponsive to dietary restrictions. No deterioration of the hearing was found in all treated patients.