Lotz C, et al. - Researchers aimed at identifying therapeutic interventions and risk factors of bleeding during extracorporeal membrane oxygenation. Findings revealed termination of extracorporeal membrane oxygenation (ECMO) support as the most successful therapeutic intervention, followed by the administration of tranexamic acid, replacement of the membrane oxygenator or the ECMO system, administration of factor VIIa, and repositioning of at least one ECMO cannula. In addition, the transfusion of platelets seemed a successful mean, as well as the utilization of desmopressin to enhance platelet function. As such, further delineation of the coagulation disorders during ECMO support to provide a sophisticated pharmacotherapy could halt this serious adverse event.