Vázquez-Costa JF, et al. - Using multivariable models, researchers assessed the contribution of demographical, clinical and genetic factors to the width of the third ventricle (WTV) in different motor neuron disease (MND) phenotypes and evaluated its brain structural correlates. By transcranial ultrasound in 107 MND patients and 25 controls, the WTV was measured. Outcomes revealed that 18 patients were diagnosed with genetic MND and 42.3% of patients exhibited executive or behavioural impairment (EBI). According to findings, the WTV was correlated significantly with age, spinal onset and the presence of EBI but not with the genetic background, the phenotype or disability. In addition, greater WTV was related to reduced subcortical grey matter volume but not with the cortical or the white matter volume. Data reported that the enlargement of the WTV found in the different MND phenotypes was due to the subcortical atrophy of grey matter and was linked to cognitive and behavioural impairment.