Li H, et al. – This study was designed to assess the vasorelaxant impact of nateglinide and its associated mechanisms using phenylephrine (Phe)–induced pre–contracted aortic rings. Findings demonstrated that nateglinide induced vasorelaxation through the activation of the voltage-dependent K⁺ (Kv) channel independent of other K⁺ channels, Ca2⁺ channels, intracellular Ca2⁺ ([Ca2⁺]_i), and the endothelium.