Asmar K, Saade C, Salman R, et al. - Researchers sought to evaluate the value of applying Apparent Diffusion Coefficient (ADC) mapping in Diffusion-Weighted Imaging (DWI) when monitoring treatment response in pediatric Osteogenic and Ewing sarcomas and to correlate with the level of necrosis on post-surgical excision pathology. This retrospective study involves 7 Osteosarcoma and 8 Ewing sarcoma individuals. The study examined pre-treatment and post-treatment focal MRIs for ADC values, tumor volumes and variability of both measurements. Furthermore, the measurement between Ewing and Osteosarcoma groups, as well as between good (=/> 90 % necrosis post-excision) and poor (<90 % necrosis post-excision) responders were compared. The data demonstrated that ADC can potentially reflect cellular changes correlated with chemotherapy use, reflecting a response to treatment. Nevertheless, quantitative use of those parameters to deliver a change in management, treatment regimen or chemotherapy dose in order to target a good response (>/ = 90 % necrosis post-excision) requires future study.