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The utility of pretreatment systemic inflammatory response biomarkers on overall survival of cervical cancer patients stratified by clinical staging

European Journal of Obstetrics & Gynecology and Reproductive Biology Jul 30, 2021

Thuler LCS, Wariss BR, Nogueira-Rodrigues A, et al. - Via performing a cohort study of women with cervical cancer (CC), researchers examined the predictive value of pretreatment inflammatory markers for the risk of death in these patients. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), derived neutrophil-lymphocyte ratio (dNLR) and a combination of PLR and NLR were the analyzed markers. The study was performed including a total of 1,266 patients; 76.0% of these had locally advanced disease. After adjusting for clinical variables, equivalent performance for predicting worse OS was displayed by NLR > 2.57, PLR ≥ 146.70,dNLR ≥ 1.778 and PLR + NLR in combination but this was observed only among patients with locally advanced disease. Overall findings support the utility of these inflammatory markers in predicting survival in patients with locally advanced disease.

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