You Y, Park JS, Min J, et al. - In out-of-cardiac arrest (OHCA) survivors who had undergone target temperature management (TTM), researchers analyzed the prognostic performance between cerebrospinal fluid (CSF) neuron-specific enolase (NSE) and serum NSE levels. Participants in the study were OHCA patients who had undergone TTM. For this single-centre prospective observational study, NSE levels were evaluated in blood and CSF samples obtained immediately (Day 0), and at 24 h (Day 1), 48 h (Day 2), and 72 h (Day 3) after return of spontaneous circulation (ROSC). The authors found that CSF NSE values in OHCA survivors treated with TTM on Day 1 after ROSC are highly predictive and sensitive markers of 6-month poor neurological outcome. CSF NSE levels can, therefore, be a useful early prognosticator in OHCA survivors on day 1 after ROSC.