Coombes L, et al. – The researchers aimed to evaluate whether there was a correlation between the effective dose of rapid onset fentanyl and background oral morphine equivalent analgesia in children less than 18 years old and to ascertain whether there was a correlation between the effective dose of rapid onset fentanyl and age and weight, they also reviewed reported side effects. In children as young as five years old, weighing as little as 13 kg, fentanyl lozenges seemed to be safe and well tolerated. Results proposed that children ought to always be started on the lowest available dose of chosen preparation and that this dose ought to be titrated according to response.