Malley Q, et al. - In the present study, the researchers sought to illustrate the novel use of prophylactic negative pressure wound therapy (NPWT) to obliterate dead space and minimize possible communication between the upper aerodigestive tract and the contents of the neck. They present a single-institutional case series of five individuals with high-risk head and neck cancer treated with NPWT after ablative and reconstructive surgery to eliminate dead space following surgical resection. Findings suggested that in the primary setting of ablative and reconstructive surgery for head and neck, NPWT can be used to treat unfilled dead space and help to prevent wound healing complications, as well as the need for secondary flap transfer.