Davidovitch R, et al. – In a study population of patients undergoing operative fixation of ankle fractures, researchers assessed the efficacy of liposomal bupivacaine versus placebo for postoperative pain control. Findings demonstrated that in cases of ankle fractures requiring Open Reduction Internal Fixation (ORIF), local intraoperative infiltration of liposomal bupivacaine administered with standard bupivacaine resulted in improved pain relief in the immediate postoperative period and hence, attenuation in Percocet ingestion, with resultant impacts visible up to 2 days postoperatively.