Chen Y, Xia Y, Xie Z, et al. - This study’s findings demonstrate that type 1 diabetes (T1D) carrying susceptible DR9/DR9 are less prone to undergo partial remission (PR). During the PR phase, the recovery extent of β-cell function tends to be lower in adults carrying DR9/DR9, which might be correlated with zinc transporter 8 antibody (ZnT8A).

• Researchers enrolled a sum of 237 T1D patients.

• According to C-peptide ≥ 300 pmol/L, PR was defined. For this study, 24 months was the median follow-up time, 65.8% (156/237) of T1D patients went into PR.

• When compared with the non-DR9/DR9 carriers, DR9/DR9 carriers had a lower PR rate (44.2% vs. 70.6%, P=0.001) and were less likely to enter PR (OR=0.218, 95% CI: 0.098-0.487, P<0.001), found in both childhoods- and adult-onset T1D.

• Besides, during the PR phase, the peak C-peptide was also lower in DR9/DR9 carriers, more notable in adult-onset T1D.

• The results showed that T1D with DR9/DR9 genotype presented an older age of onset and a lower positivity of ZnT8A when compared with non-DR9/DR9 carriers, and the lower trend of ZnT8A was only found in adult-onset T1D (P=0.049).