Zong L, Zhang Q, Kong Y, et al. - By performing this retrospective analysis in patients (n = 384) with node-positive squamous cell carcinoma of the cervix (2018 FIGO stage IIIC) who had radical surgery between January 2005 and December 2016, researchers focused on the worth of the tumor-stroma ratio (TSR) while recognizing prognostic factors in these patients after primary radical surgery. The evaluation of TSRs was done on hematoxylin and eosin-stained tumor slides, followed by grouping as stroma-low (< 50% stroma) or stroma-high (≥ 50% stroma). The factors that were independently predictive of shorter disease-free survival and overall survival were a tumor size ≥ 4 cm, ≥ 3 metastatic lymph nodes, and stroma-high status, as revealed in multivariate analysis. In this study, the TSR was identified as an independent prognostic factor. Furthermore, findings revealed good discriminative ability displayed by a prognostic scoring system including this parameter for both recurrence and survival in patients with 2018 FIGO stage IIIC cervical cancer post-radical surgery. Overall, the TSR represents a potentially new clinicopathological variable for foretelling the prognoses of these patients contingent on the validation of these findings.