Simental–Mendía LE, et al. – The clinicians wished to figure out whether triglycerides and glucose (TyG) index was associated with cardiovascular risk factors in apparently healthy normal–weight children and adolescents. Their findings confirmed that the elevated TyG index was associated with the presence of cardiovascular risk factors in healthy normal–weight children and adolescents.

Methods

• This study included apparently healthy children and adolescents with normal weight, aged 6–15 years.
• The children were divided into groups with and without cardiovascular risk factors. 
• Cardiovascular risk factors were considered as the occurrence of at least one of the following: elevated blood pressure, hypertriglyceridemia, low high–density lipoprotein cholesterol (HDL–C), or hyperglycemia.

Results

• This study included 2,117 children and adolescents.
• 1,078 (50.9%) participants exhibited cardiovascular risk.
• The adjusted logistic regression analysis revealed that elevated TyG index was significantly associated with hypertriglyceridemia (odds ratio (OR)=96.45, 95% confidence interval (CI): 48.44–192.04), low HDL–C (OR=2.07, 95% CI: 1.46–2.92), and hyperglycemia (OR=3.11, 95% CI: 2.05–4.72), but not with elevated blood pressure (OR=1.39, 95% CI: 0.89–2.16).