Kuniyoshi S, et al. - Through a study, the researchers intended to determine the importance of lipid accumulation in breast carcinoma cells via focusing on perilipin 2 (included in constituting the intracellular lipid composition) and its clinicopathological significance. In 105 subjects of breast cancer, perilipin 2 was first immunolocalized. A positively significant correlation of perilipin 2 immunoreactivity with histological grade, Ki-67 labeling index and HER2 status and negatively with estrogen receptor status of these subjects was observed. In comparison to cells of other subtypes, mRNA expression of perilipin 2 in triple negative breast carcinoma cells was discovered as greater. The association between perilipin 2 immunoreactivity and intracellular lipid droplet assessed by Oil-red O stating in 13 cases of breast carcinoma tissues was studied and a significantly positive association was recognized among the status of perilipin 2 and Oil-red O staining. Hence, in surgical pathology specimens of breast cancer, it was observed that perilipin 2 could signify the status of intracellular lipid droplets and it was also affiliated with its more aggressive biological phenotypes.