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The SH2B3 and KCNK5 loci may be implicated in regulation of platelet count, volume, and maturity

Thrombosis Research Aug 31, 2017

Christiansen MK, et al. – The aim of this study was to explore the correlation between CAD and MI–correlated genetic variants and five thrombopoiesis–related indices: platelet count (PC), mean platelet volume (MPV), immature platelet count (IPC), immature platelet fraction (IPF), and serum thrombopoietin (TPO). The data indicates a role for KCNK5 in the regulation of platelet size and maturity. Furthermore, the findings confirm an association between the SH2B3–locus and platelet count.
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