Garau LM, et al. - Given some debate surrounding the accuracy of sentinel lymph node biopsy (SNB) technique in the management of papillary thyroid carcinoma (PTC) because of wide heterogeneity of sentinel lymph node detection and false-negative findings, researchers sought to recognize the key issues which make the usefulness of SNB in PTC difficult. Performing a comprehensive computer literature search in PubMed/MEDLINE and Cochrane Library database until June 30, 2019, they identified 4 written meta-analyses published in the literature. The analysis revealed reporting of relatively high false-negative rates for each SNB methods: vital-dye (VD: 12.7%; 7%; 0-38%), 99mTc-nanocolloid planar lymphoscintigraphy with the use of intraoperative hand-held gamma probes (LS: 11.3%; 16%; 0-40%), combined LS with VD (LS+VD: 0%; 0-17%), LS with the additional contribution of preoperative SPECT/CT (7-8%). Observations revealed the increasing evidence-based data concerning the diagnostic performance of SNB in PTC. They suggest a consensus should be reached on the operational definition of the SLN by the nuclear medicine community to better guide the surgeon in recognizing the lymph nodes most likely contain metastatic cells. The necessity for standardization of SLN identification, removal, and analysis is highlighted.