Suzuki M, et al. - Here, researchers establish the effects of these drugs on placental growth factor (PlGF) and regulating factors of protein kinase R-like endoplasmic reticulum kinase (PERK) pathway; expression of activating transcription factor 4 (ATF4) and phosphorylation of eukaryotic initiation factor 2 subunit α (p-eIF2α). In light of these outcomes, metformin and pravastatin suppressed ER stress and activation of the PERK pathway and restored PlGF levels in trophoblast-like cells. These outcomes indicate that metformin and pravastatin have a potential for preventing or treating PE.