Song F, Zhou Y, Zhang K, et al. - Researchers undertook this longitudinal, observational, retrospective analysis to determine if prognosis in patients with acute coronary syndrome (ACS) could be predicted by the glycosylated hemoglobin A1c (HbA1c)/apolipoprotein A-l (ApoA-l) ratio. This study involved 476 ACS patients diagnosed using coronary angiography. Stratification of patients by the tertiles of HbA1c/ApoA-l concentrations was done. A 4.36-fold elevated risk of death was observed in patients in the highest HbA1c/ApoA-l ratio tertile vs patients in the lowest tertile, following adjustment for age, gender, smoking, hypertension, diabetes, and coronary artery disease severity. Overall, in ACS patients receiving angiography, all-cause mortality and major adverse cardiovascular events were shown to be independently predicted by the HbA1c/ApoA-1 ratio, following adjustment for traditional cardiovascular risk factors and ACS severity scores.