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The role of soluble E-selectin in HIV associated preeclampsia

European Journal of Obstetrics & Gynecology and Reproductive Biology Dec 14, 2020

Naidoo G, Khaliq OP, Moodley J, et al. - The serum concentration of soluble E-selectin (sE-selectin) was determined in HIV associated preeclampsia. Researchers here used MilliPlex multiplex immunoassay to quantify serum concentrations of sE-selectin in normotensive pregnant (n = 36) and preeclamptic ( n = 36) women stratified by HIV status (negative vs positive). Analysis revealed that preeclamptic HIV-negative group had an elevation of sE-selectin compared with the normotensive HIV-negative group. However, when stratified by HIV status, no significant difference was noted in preeclamptic HIV-positive and normotensive HIV-positive groups. The findings of this small-scale study suggest the possible utility of sE-selectin as a biomarker or an early identifier of preeclampsia.

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