Gyawali P, et al. - Researchers attempted to investigate prospective associations of sex hormone-binding globulin (SHBG) and sex steroids with incident type 2 diabetes (T2D) in a cohort of community-dwelling men. Study participants were from a cohort study of community-dwelling (n = 2,563), middle-aged to elderly men (35–80 years) from Adelaide, Australia (the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study). They used logistic binomial regression to evaluate relationships between SHBG, sex steroids and incident T2D, adjusting for confounders including age, smoking status, physical activity, adiposity, glucose, triglycerides, symptomatic depression, SHBG and sex steroid levels. Results of this study suggested that low total testosterone (TT), but not SHBG and other sex steroids best predicted the development of T2D after adjustment for confounders in men.