Shirali AS, Wu JX, Zhu CY, et al. - In patients with hypothyroidism vs those who have euthyroidism, researchers evaluated the test performance of serum procalcitonin (PCT) in anticipating bacterial sepsis and septic shock. From a prospectively maintained database who had PCT testing from 2005 to 2018, they identified patients with no history of thyroid dysfunction (euthyroid), primary hypothyroidism [medical hypothyroidism (MH)], and postsurgical hypothyroidism from total thyroidectomy (TT). Two hundred seventeen euthyroid patients, 197 patients with MH, and 84 patients with TT were identified in this retrospective study. Bacterial sepsis was observed in 98, 92, and 36 of these individuals, respectively. Overall, the authors concluded that hypothyroidism did not influence the diagnostic performance of serum PCT levels in anticipating bacterial sepsis or septic shock in spite of the thyroidal origin of PCT.