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The role of serum adipokine levels in preeclampsia: A systematic review

Metabolism Feb 10, 2020

Daskalakis G, et al. - Via systematically searching Medline, Scopus, CENTRAL, Clinicaltrials.gov, and Google Scholar databases from inception, researchers sought to investigate the pattern of serum adipokine levels among preeclamptic women and evaluate their potential effectiveness in the prediction of the disease. Among preeclamptic and healthy pregnant women, all observational studies reporting serum adipokine values were held eligible. In total, 163 studies comprising 23,482 women were involved. In all pregnancy trimesters and forms of the disease, preeclampsia was associated with increased levels of leptin, chemerin, and fatty acid binding protein-4. There are currently inconsistent data regarding the role of the other adipokines. Large-scale prospective studies will assess the serum concentration of novel adipokines longitudinally and identify the optimal threshold and timing of the measurement to be applied widely in clinical practice.
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