Zorrilla-Vaca A, et al. - This investigation was pursued to determine the benefits of the sciatic nerve block (SNB) as a complement to femoral nerve block (FNB), as well as to compare the efficacy of single-injection vs continuous SNB in total knee arthroplasty (TKA). The benefits of SNB as a complement to FNB in TKA were supported by the evidence obtained from randomized controlled trials in this meta-analysis. For patients at high risk of postoperative opioids consumption or acute pain after TKA, the combination sciatic–femoral nerve block appeared to be the optimal choice.