Bonaventura A, Carbone F, Vecchie A, et al. - This study was attempted to assess the prognostic role of resistin and myeloperoxidase (MPO) in sepsis. Researchers assessed plasma resistin and MPO on days 1, 2, and 7 in 957 patients enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial. The relationship between resistin and MPO levels on days 1, 2, and 7 and 90‐day mortality was evaluated. It was shown that high levels of MPO, but not of resistin, on day 1 were able to prognosticate 90‐day mortality. These data may either imply that early hyper‐activation of neutrophils is detrimental in patients with sepsis or reflect the burden of the inflammatory process caused by sepsis.