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The role of regional disease and patterns of treatment failure in primary sinonasal malignancies

American Journal of Rhinology & Allergy Jul 29, 2021

Meerwein CM, Balermpas P, Vital DG, et al. - Researchers conducted this retrospective cohort study to examine patterns of treatment failure and to evaluate outcome measures in patients with primary sinonasal malignancies. The sample consisted of 152 patients treated for primary malignant sinonasal malignancies. At the time of initial presentation, 8 of 152 patients (5.3%) had lymph node (LN) metastases. The authors observed a 5-year overall survival (OS) of 75.2% and disease-free survival of 61.1%. LN metastases at initial presentation are uncommon, and the most important prognostic factor for OS and complete remission was identified as initial T classification, emphasising the importance of the thorough initial staging of the primary tumor.

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