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The role of radiotherapy in resected R0/R+ pancreatic cancer: A real-life single-institution experience

American Journal of Clinical Oncology Mar 05, 2020

Lutsyk M, et al. - Researchers examined the role of external radiation therapy following resection of pancreatic cancer via assessing cases who underwent either Whipple procedure or distal pancreatectomy and received either chemo-radiotherapy (chemo-rad) or chemotherapy alone (R0 chemo). Participants received chemotherapy (chemo) based on cisplatin and either gemcitabine or 5 FU/leukovorin. They were provided the total radiation dose of 50.4 Gy given in 1.8 Gy 5 times a week. During the years 2000 to 2018, 734 patients were referred; of these, 134 underwent either Whipple procedure or distal pancreatectomy. Complete tumor resection was achieved in 93 (R0 group), and involved resection margins were observed in 41 (R+ group). Treatment with R0 chemo was provided to an overall 49 of the 93 patients, and treatment with chemo-rad (R0 chemo-rad) was provided to 44 patients. Outcomes revealed significant improvement in the overall survival of R+ resected pancreatic cancer but not of positive nodes patients in correlation to receiving external radiation therapy.
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