Meli L, et al. - Experts aspired to investigate whether perceived threat during acute coronary syndrome (ACS) evaluation mediated the relationship between age and posttraumatic stress symptoms (PSS) after ACS evaluation in an observational cohort study of patients presenting to the Emergency Department (ED) with suspected ACS. Compared to older individuals, younger individuals were at risk for greater PSS after ACS evaluation. This association was partially mediated by elevated perceived threat. Understanding age differences in PSS development risk and the potential impact of age on threat perceptions could be helpful in inform ED treatment.