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The role of neutrophil gelatinase-associated lipocalin (NGAL) in the detection of blast lung injury in a military population

Journal of Critical Care Sep 07, 2017

Lumley A, et al. – This study assessed the potential of neutrophil gelatinase–associated lipocalin (NGAL) for being a biomarker for blast lung injury (BLI). In order to accomplish this goal, researchers studied the link between serum NGAL and military blast and gunshot wound (GSW). In both patient groups, a correlation was evident, of elevated NGAL with increased severity of injury (worse survival probability i.e. [trauma injury severity score (TRISS) and low pH). Furthermore, in blast injured group but not GSW group, data reported an inverse correlation between admission NGAL and a marker of blast lung injury (low P/F ratio) at 24 h.
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