Guo T, Qin Y, Gao X, et al. - Researchers aimed at ascertaining if and how chromosomal polymorphism in men affects spermatogenesis and the outcome of IVF/ICSI‐ET. Among 281 retrospectively analysed infertile couples, polymorphism‐carrying men with severe oligozoospermia had significantly, lower fertilization rate (68.02% vs 78.00%) and clinical pregnancy rate (45.00% vs 66.67%) compared with non‐carriers with severe oligozoospermia. Outcomes here indicate adverse effects of chromosomal polymorphism on spermatogenesis, which negatively influence the outcome of IVF/ICSI‐ET treatment. In infertile men, the most prevalent polymorphism identified was polymorphic variations on the Y chromosome; it most frequently occurred in patients with severe oligozoospermia.