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The role of Gabapentin oral solution in decreasing desflurane associated emergence agitation and delirium in children after stabismus surgery: A prospective randomized double-blind study

BMC Anesthesiology Jun 26, 2018

Badawy AA, et al. - In this study involving children, 2–6 years old, who underwent strabismus surgery under general anesthesia, researchers investigated if Gabapentin oral solution is efficacious for reducing desflurane associated emergence agitation (EA). They examined two groups; Control group (c): received 5 ml of oral strawberry juice (placebo) and Gabapentin group (G) received 5 mg/Kg gabapentin oral solution in 5 ml strawberry juice, 1 h before anesthesia, to assess patient separation, cooperation, emergence incidence and emergence severity as well as on time to extubation and time to emergence, duration of post-anesthesia care unit (PACU) stay, postoperative nausea and vomiting (PONV) and number of patients required meperidine postoperatively. They found that reduced incidence and severity scoring of emergence agitation (by 20%) was achieved with oral gabapentin 5 mg/kg, with more tendencies for sleeping with preserved response to stimuli in PACU.
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