Sullivan EV, et al. - Researchers sought to combine cross-sectional, longitudinal data to test age-alcoholism interactions. In addition, they examined the association between prevalent comorbidities (drug dependence and hepatitis C virus [HCV] infection) and cortical volume deficits in alcohol dependence. Drug dependence and HCV infection intensified deleterious effects of alcohol dependence on frontal cortical volumes. However, in the drug-free participants with alcoholism, these could not account for the frontally distributed volume deficits. It was noted that age-alcohol interactions notable in frontal cortex put older adults at heightened risk for age-associated neurocompromise even if alcohol misuse is initiated later in life.