Yang Q, et al. - Researchers investigated the associations of 27 gut microbiota genera with ischemic heart disease, type 2 diabetes mellitus, adiposity, lipids and insulin resistance using summary data from CARDIoGRAAMplusC4D and other consortiums. They obtained estimates of these links by using separate-sample Mendelian randomization. They found nominal associations of Acidaminococcus, Aggregatibacter, Anaerostipes, Blautia, Desulfovibrio, Dorea and Faecalibacterium with type 2 diabetes mellitus or other risk factors. They also noted a lower risk of ischemic heart disease and 0.011 standard deviation lower body mass index, but 0.026 standard deviation higher low-density lipoprotein cholesterol (which, however, were not robust to exclusion of potential pleiotropy) in relation to a 1 allele increase in single nucleotide polymorphisms related to higher Bifidobacterium.