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The risk of heart failure and other cardiovascular hospitalizations after early stage breast cancer: A matched cohort study

Journal of the National Cancer Institute Feb 04, 2019

Abdel-Qadir H, et al. - In this population-based, retrospective cohort study of 78,318 early stage breast cancer (EBC) patients (diagnosed April 1, 2005–March 31, 2015) matched 1:3 on birth-year to cancer-free control subjects (n=234,954), researchers determined the risk of heart failure (HF) necessitating hospital-based care following EBC and how it relates to other types of cardiovascular disease (CVD) by using cumulative incidence function curves and cause-specific regression models. Over 10 years, an incidence of 10.8% for CVD hospitalization was reported following EBC, while it was 9.1% in control subjects. CVD hospitalization in most of the cases following EBC was attributed to atherosclerotic diagnoses, not HF. Risk factors such as age >60 years, hypertension, diabetes, and prior CVD, often preceded HF hospital presentations. A total of 28,950 EBC patients were treated with anthracycline and/or trastuzumab and relative higher rates of CVD were observed in these subjects vs age-matched control subjects.

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