Lin YH, et al. - In this study involving outpatients with ≥ 1 cardiovascular risk, researchers consecutively evaluated various arterial pulse-wave velocity (PWV) indices and ankle-brachial index (ABI) by an automatic device (VP2000, OMRON Health Care Co. Ltd., Kyota, Japan). ABI ≤ 0.9 was used to define PAD. They found independent associations between lower eGFR, lower ABI, higher hf-PWV and greater PAD risk, using multivariate regression models. For detecting PAD, eGFR set at 77 mL/min/1.73m² was observed to be a useful clinical cutoff when superimposed on clinical risks. Overall, findings demonstrated a tight link of early renal insufficiency with region-specific vascular stiffness and PAD.