Huang S, et al. – The clinicians examined the association between the GJB3 c.538C > T variant and hearing phenotype in a Chinese population in order to assist the risk assessment and genetic counseling for patients with hearing loss. They reported a very low incidence of GJB3 c.538C > T variant in the Chinese population. In addition, they found no clear evidence regarding the role of the GJB3 c.538C > T variant in the autosomal dominant form of non-syndromic deafness. Thus, these findings would help in the genetic counseling and risk prediction for deafness related to the GJB3 c.538C > T variant.