Husted RS, Juhl C, Troelsen A, et al. - Via performing this systematic review, researchers sought to evaluate the correlation between prescribed knee-extensor strength exercise dosage in preoperative exercise intervention and the effect on kneeextensor muscle strength prior to and following total knee arthroplasty (TKA). Additional meta-analyses were performed to report on the effect of prehabilitation on outcomes prior to and following TKA. Inclusion of 12 trials with 616 patients was performed. Outcomes from meta-regression analysis of existing trials indicated no correlation between the prescribed preoperative kneeextensor exercise dosage and the change in knee-extensor strength observed prior to and following TKA. Moderate increase in knee-extensor strength was observed prior to but not 3 months following TKA in correlation with preoperative exercise including knee-extensor muscle strength exercise.