Cheng G, et al. – This paper analyzed the link between glycemic variability and coronary collateral formation in patients with type 2 diabetes mellitus and coronary artery disease (CAD). Findings demonstrated no association between glycemic variability and coronary collateral artery formation in the studied patient population.

Methods

• Researchers studied consecutive patients undergoing percutaneous coronary intervention or coronary artery bypass grafting procedures.
• They used multivariate logistic regression models to assess the link between coronary artery collateral formation graded by Rentrope classification and glycemic variability, measured by coefficient variation of fasting blood glucose.

Results

• This study included retrospective enrollment of 300 patients, of whom 239 were diabetic (age: 70.1±11.9, 56% men) and 61 were nondiabetic (age: 71.5±11.5, 72% men).
• Data reported that diabetic patients were further stratified as follows: those with poor coronary collateral artery development (n=171, age: 69.7±12.4, 55% men) and those with good coronary collateral artery development (n=68, age 71.1±10.8, 59% men) according to the Rentrope classification.
• Researchers found no association between glycemic variability and coronary collateral vessels development after controlling for potential confounders (odds ratio: 2.51; 95% confidence interval: 0.57–11.03; P=0.22).
• They noted that the culprit lesion (≥75% stenosis) in the left anterior descending artery and the right coronary artery was more frequent in the good collateral group compared with the poor collateral group (66 vs. 50%, P=0.02; 63 vs. 45%, P=0.01 respectively).