Wang X, Song X, Cheng G, et al. - In this investigation involving 90 pairs of gastric cancer tissues and adjacent normal tissues, researchers sought to observe the clinical implications and biological functions of mitochondrial calcium uniporter (MCU), a selective channel responsible for mitochondrial Ca2+ uptake, in gastric cancer. There was a a higher expression of MCU in gastric cancer tissues than normal tissues. Depth of invasion, lymph metastasis, TNM stage, and distant metastasis were significantly associated with MCU expression. A worse prognosis was seen in patients with high MCU expression vs those with a low expression. MCU promoted migration and invasion of gastric cancer cells, as seen in wound healing and transwell assay results. These results indicated that gastric cancer migration, invasion, angiogenesis and growth could be promoted by highly expressed MCU, meaning it could become a potential gastric cancer therapeutic marker.