Martel-Pelletier J, et al. - Researchers investigated the associative value of a panel of adipokines and some related inflammatory factors alone at assessing cartilage volume loss over time and symptoms in obese (High BMI) and non-obese (Low BMI) osteoarthritis (OA) subjects. From the Osteoarthritis Initiative Progression subcohort, they assessed human OA serum to study their levels of the nine biomarkers and their ratios (36). Findings revealed that the cartilage volume loss over time in the lateral compartment was associated with the ratio adipsin/MCP-1 and that CRP/MCP-1 was associated with symptoms in obese OA subjects. Findings thereby highlight the significance of ratios as biomarkers to a stronger association to OA progression and symptoms.