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The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

Cancer Medicine Jun 12, 2021

Yu H, Wang M, Wang Y, et al. - This prospective cohort study was undertaken to determine the prognostic worth of the fibrinogen–albumin ratio (FAR) combined with sarcopenia in intrahepatic cholangiocarcinoma (ICC) patients post-surgery, as well as to construct a nomogram for survival prediction of ICC patients. The discovery cohort included 116 ICC patients who had radical surgery. The validation cohort comprised another independent cohort of 68 ICC patients. Based on age, FAR, and sarcopenia, overall survival (OS) nomogram was developed. Researchers built recurrence-free survival (RFS) nomogram based on FAR and sarcopenia. Estimated C-index was 0.713 and 0.686 for the nomograms of OS and RFS. The nomograms of OS and RFS generated an area under ROC curve (AUC) of 0.796 and 0.791 in the discovery cohort, and 0.823 and 0.726 in the validation cohort, respectively. Via decision curve analysis, clinical value of nomograms was corroborated. A poor prognosis was seen in ICC patients with high FAR and sarcopenia, and accuracy as well as clinical usefulness of the nomograms built based on these two factors was evident in ICC patients who received radical resection.

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