Sand FL, et al. - Since prognostic value of tumor suppressor proteins p16 and p53 has been suggested in some human papillomavirus (HPV)-associated cancers, researchers determined how survival after vulvar squamous cell carcinoma (VSCC) could be affected by p16 and p53 expression status. For this purpose, they analyzed evidence from studies examining survival after histolocally verified VSCC that were tested for p16 and/or p53. The 18 eligible studies, included in this systematic review and meta-analysis, were identified by a thorough systematic literature search of multiple databases. According to findings obtained in this study, p53 and especially p16 expression status were shown to have prognostic importance in women diagnosed with VSCC. This could have a clinical significance in the future design of targeted therapy and when planning the optimal follow-up strategy.