Lammers MJW, et al. - In this systematic review and meta-analysis, researchers determined the value of three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) MRI in identifying labyrinthine signal alterations in patients with idiopathic sudden sensorineural hearing loss (ISSNHL), as well as explored whether hyperintensity on 3D-FLAIR was correlated with the extent of hearing loss in these patients. The inclusion criteria were met by eight observational research (n = 638 patients). Findings suggested that 3D-FLAIR MR imaging can identify an underlying labyrinthine condition in up to 29% of patients with sudden hearing loss in whom earlier no cause could be identified. Their final pure-tone averages are more than 20dB worse than 3D-FLAIR negative patients, indicating more serious harm to labyrinthine. Such findings can contribute to the comprehension of ISSNHL's pathophysiological mechanisms.